The risk of dependency is relatively low when the drug is administered for only short periods of time (for example, as treatment to reduce nausea and vomiting produced by chemotherapy). In the case of longer-term treatments (for pain, multiple sclerosis, etc.), the risk of dependency is greater, and in such cases it is very important to duly evaluate the benefit/risk ratio, and make decisions accordingly.

Some users manifest a withdrawal syndrome when they suddenly stop consuming the drug. This syndrome, which is moderate in intensity, is characterized by irritability, nervousness, sleep disorders, hyperhidrosis (excessive perspiration) and anorexia.

It should be pointed out that dependency in these situations is determined more by the psychological than the physical factors.